Intranasal vaccination with recombinant receptor-binding domain of MERS-CoV spike protein induces much stronger local mucosal immune responses than subcutaneous immunization: Implication for designing novel mucosal MERS vaccines
Identifieur interne : 001C13 ( Main/Exploration ); précédent : 001C12; suivant : 001C14Intranasal vaccination with recombinant receptor-binding domain of MERS-CoV spike protein induces much stronger local mucosal immune responses than subcutaneous immunization: Implication for designing novel mucosal MERS vaccines
Auteurs : Cuiqing Ma [États-Unis, République populaire de Chine] ; Ye Li [États-Unis] ; Lili Wang [États-Unis] ; Guangyu Zhao [République populaire de Chine] ; Xinrong Tao [États-Unis] ; Chien-Te K. Tseng [États-Unis] ; Yusen Zhou [République populaire de Chine] ; Lanying Du [États-Unis] ; Shibo Jiang [États-Unis, République populaire de Chine]Source :
- Vaccine [ 0264-410X ] ; 2014.
Descripteurs français
- KwdFr :
- Administration par voie nasale, Animaux, Anticorps antiviraux (sang), Anticorps neutralisants (sang), Cellules HEK293, Coronavirus (), Coronavirus (immunologie), Femelle, Fragments Fc des immunoglobulines (immunologie), Glycoprotéine de spicule des coronavirus (immunologie), Humains, Immunité cellulaire, Immunité humorale, Immunité muqueuse, Immunoglobuline G (sang), Injections sous-cutanées, Poumon (immunologie), Protéines recombinantes (immunologie), Rate (immunologie), Souris, Souris de lignée BALB C, Vaccins antiviraux (immunologie).
- MESH :
- immunologie : Coronavirus, Fragments Fc des immunoglobulines, Glycoprotéine de spicule des coronavirus, Poumon, Protéines recombinantes, Rate, Vaccins antiviraux.
- sang : Anticorps antiviraux, Anticorps neutralisants, Immunoglobuline G.
- Administration par voie nasale, Animaux, Cellules HEK293, Coronavirus, Femelle, Humains, Immunité cellulaire, Immunité humorale, Immunité muqueuse, Injections sous-cutanées, Souris, Souris de lignée BALB C.
English descriptors
- KwdEn :
- Administration, Intranasal, Animals, Antibodies, Neutralizing (blood), Antibodies, Viral (blood), Coronavirus (classification), Coronavirus (immunology), Female, HEK293 Cells, Humans, Immunity, Cellular, Immunity, Humoral, Immunity, Mucosal, Immunoglobulin Fc Fragments (immunology), Immunoglobulin G (blood), Injections, Subcutaneous, Lung (immunology), Mice, Mice, Inbred BALB C, Recombinant Proteins (immunology), Spike Glycoprotein, Coronavirus (immunology), Spleen (immunology), Viral Vaccines (immunology).
- MESH :
- chemical , blood : Antibodies, Neutralizing, Antibodies, Viral, Immunoglobulin G.
- classification : Coronavirus.
- immunology : Coronavirus, Immunoglobulin Fc Fragments, Lung, Recombinant Proteins, Spike Glycoprotein, Coronavirus, Spleen, Viral Vaccines.
- Administration, Intranasal, Animals, Female, HEK293 Cells, Humans, Immunity, Cellular, Immunity, Humoral, Immunity, Mucosal, Injections, Subcutaneous, Mice, Mice, Inbred BALB C.
Abstract
We compared MERS-CoV RBD-induced immune responses I.n. induced comparable systemic humoral immune responses as s.c. I.n. induced similar neutralization but more robust cellular responses than s.c. I.n. elicited significantly higher local mucosal immune responses than s.c. Has potential to be developed as an effective and safe MERS mucosal vaccine.
Url:
DOI: 10.1016/j.vaccine.2014.02.004
PubMed: 24560617
PubMed Central: 4194189
Affiliations:
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Le document en format XML
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Kimball Research Institute, New York Blood Center, New York, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0030">Department of Immunology, Hebei Medical University, Shijiazhuang, Hebei, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Immunology, Hebei Medical University, Shijiazhuang, Hebei</wicri:regionArea><wicri:noRegion>Hebei</wicri:noRegion></affiliation></author><author><name sortKey="Li, Ye" sort="Li, Ye" uniqKey="Li Y" first="Ye" last="Li">Ye Li</name><affiliation wicri:level="2"><nlm:aff id="aff0005">Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Wang, Lili" sort="Wang, Lili" uniqKey="Wang L" first="Lili" last="Wang">Lili Wang</name><affiliation wicri:level="2"><nlm:aff id="aff0005">Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Zhao, Guangyu" sort="Zhao, Guangyu" uniqKey="Zhao G" first="Guangyu" last="Zhao">Guangyu Zhao</name><affiliation wicri:level="3"><nlm:aff id="aff0010">State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Tao, Xinrong" sort="Tao, Xinrong" uniqKey="Tao X" first="Xinrong" last="Tao">Xinrong Tao</name><affiliation wicri:level="2"><nlm:aff id="aff0015">Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Tseng, Chien Te K" sort="Tseng, Chien Te K" uniqKey="Tseng C" first="Chien-Te K." last="Tseng">Chien-Te K. Tseng</name><affiliation wicri:level="2"><nlm:aff id="aff0015">Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff0020">Center for Biodefense and Emerging Disease, University of Texas Medical Branch, Galveston, TX, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Biodefense and Emerging Disease, University of Texas Medical Branch, Galveston, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Zhou, Yusen" sort="Zhou, Yusen" uniqKey="Zhou Y" first="Yusen" last="Zhou">Yusen Zhou</name><affiliation wicri:level="3"><nlm:aff id="aff0010">State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Du, Lanying" sort="Du, Lanying" uniqKey="Du L" first="Lanying" last="Du">Lanying Du</name><affiliation wicri:level="2"><nlm:aff id="aff0005">Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Jiang, Shibo" sort="Jiang, Shibo" uniqKey="Jiang S" first="Shibo" last="Jiang">Shibo Jiang</name><affiliation wicri:level="2"><nlm:aff id="aff0005">Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0025">Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, Shanghai Medical College and Institute of Medical Microbiology, Fudan University, Shanghai, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, Shanghai Medical College and Institute of Medical Microbiology, Fudan University, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author></analytic><series><title level="j">Vaccine</title><idno type="ISSN">0264-410X</idno><idno type="eISSN">1873-2518</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Administration, Intranasal</term><term>Animals</term><term>Antibodies, Neutralizing (blood)</term><term>Antibodies, Viral (blood)</term><term>Coronavirus (classification)</term><term>Coronavirus (immunology)</term><term>Female</term><term>HEK293 Cells</term><term>Humans</term><term>Immunity, Cellular</term><term>Immunity, Humoral</term><term>Immunity, Mucosal</term><term>Immunoglobulin Fc Fragments (immunology)</term><term>Immunoglobulin G (blood)</term><term>Injections, Subcutaneous</term><term>Lung (immunology)</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Recombinant Proteins (immunology)</term><term>Spike Glycoprotein, Coronavirus (immunology)</term><term>Spleen (immunology)</term><term>Viral Vaccines (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Administration par voie nasale</term><term>Animaux</term><term>Anticorps antiviraux (sang)</term><term>Anticorps neutralisants (sang)</term><term>Cellules HEK293</term><term>Coronavirus ()</term><term>Coronavirus (immunologie)</term><term>Femelle</term><term>Fragments Fc des immunoglobulines (immunologie)</term><term>Glycoprotéine de spicule des coronavirus (immunologie)</term><term>Humains</term><term>Immunité cellulaire</term><term>Immunité humorale</term><term>Immunité muqueuse</term><term>Immunoglobuline G (sang)</term><term>Injections sous-cutanées</term><term>Poumon (immunologie)</term><term>Protéines recombinantes (immunologie)</term><term>Rate (immunologie)</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Vaccins antiviraux (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Neutralizing</term><term>Antibodies, Viral</term><term>Immunoglobulin G</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Coronavirus</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Coronavirus</term><term>Fragments Fc des immunoglobulines</term><term>Glycoprotéine de spicule des coronavirus</term><term>Poumon</term><term>Protéines recombinantes</term><term>Rate</term><term>Vaccins antiviraux</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Coronavirus</term><term>Immunoglobulin Fc Fragments</term><term>Lung</term><term>Recombinant Proteins</term><term>Spike Glycoprotein, Coronavirus</term><term>Spleen</term><term>Viral Vaccines</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antiviraux</term><term>Anticorps neutralisants</term><term>Immunoglobuline G</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Administration, Intranasal</term><term>Animals</term><term>Female</term><term>HEK293 Cells</term><term>Humans</term><term>Immunity, Cellular</term><term>Immunity, Humoral</term><term>Immunity, Mucosal</term><term>Injections, Subcutaneous</term><term>Mice</term><term>Mice, Inbred BALB C</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Administration par voie nasale</term><term>Animaux</term><term>Cellules HEK293</term><term>Coronavirus</term><term>Femelle</term><term>Humains</term><term>Immunité cellulaire</term><term>Immunité humorale</term><term>Immunité muqueuse</term><term>Injections sous-cutanées</term><term>Souris</term><term>Souris de lignée BALB C</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Highlights</title><p><list list-type="simple" id="lis0005"><list-item id="lsti0005"><label>•</label><p id="par0005">We compared MERS-CoV RBD-induced immune responses <italic>via</italic> i.n. and s.c. routes.</p></list-item><list-item id="lsti0010"><label>•</label><p id="par0010">I.n. induced comparable systemic humoral immune responses as s.c.</p></list-item><list-item id="lsti0015"><label>•</label><p id="par0015">I.n. induced similar neutralization but more robust cellular responses than s.c.</p></list-item><list-item id="lsti0020"><label>•</label><p id="par0020">I.n. elicited significantly higher local mucosal immune responses than s.c.</p></list-item><list-item id="lsti0025"><label>•</label><p id="par0025">Has potential to be developed as an effective and safe MERS mucosal vaccine.</p></list-item></list></p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Zaki, A M" uniqKey="Zaki A">A.M. 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Do</name></author><author><name sortKey="Didierlaurent, A M" uniqKey="Didierlaurent A">A.M. Didierlaurent</name></author><author><name sortKey="Ryu, S" uniqKey="Ryu S">S. Ryu</name></author><author><name sortKey="Koh, H" uniqKey="Koh H">H. Koh</name></author><author><name sortKey="Park, C G" uniqKey="Park C">C.G. Park</name></author><author><name sortKey="Park, S" uniqKey="Park S">S. Park</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>République populaire de Chine</li><li>États-Unis</li></country><region><li>Texas</li><li>État de New York</li></region><settlement><li>Pékin</li></settlement></list><tree><country name="États-Unis"><region name="État de New York"><name sortKey="Ma, Cuiqing" sort="Ma, Cuiqing" uniqKey="Ma C" first="Cuiqing" last="Ma">Cuiqing Ma</name></region><name sortKey="Du, Lanying" sort="Du, Lanying" uniqKey="Du L" first="Lanying" last="Du">Lanying Du</name><name sortKey="Jiang, Shibo" sort="Jiang, Shibo" uniqKey="Jiang S" first="Shibo" last="Jiang">Shibo Jiang</name><name sortKey="Li, Ye" sort="Li, Ye" uniqKey="Li Y" first="Ye" last="Li">Ye Li</name><name sortKey="Tao, Xinrong" sort="Tao, Xinrong" uniqKey="Tao X" first="Xinrong" last="Tao">Xinrong Tao</name><name sortKey="Tseng, Chien Te K" sort="Tseng, Chien Te K" uniqKey="Tseng C" first="Chien-Te K." last="Tseng">Chien-Te K. Tseng</name><name sortKey="Tseng, Chien Te K" sort="Tseng, Chien Te K" uniqKey="Tseng C" first="Chien-Te K." last="Tseng">Chien-Te K. Tseng</name><name sortKey="Wang, Lili" sort="Wang, Lili" uniqKey="Wang L" first="Lili" last="Wang">Lili Wang</name></country><country name="République populaire de Chine"><noRegion><name sortKey="Ma, Cuiqing" sort="Ma, Cuiqing" uniqKey="Ma C" first="Cuiqing" last="Ma">Cuiqing Ma</name></noRegion><name sortKey="Jiang, Shibo" sort="Jiang, Shibo" uniqKey="Jiang S" first="Shibo" last="Jiang">Shibo Jiang</name><name sortKey="Zhao, Guangyu" sort="Zhao, Guangyu" uniqKey="Zhao G" first="Guangyu" last="Zhao">Guangyu Zhao</name><name sortKey="Zhou, Yusen" sort="Zhou, Yusen" uniqKey="Zhou Y" first="Yusen" last="Zhou">Yusen Zhou</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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